The ENSA Antibody (Center) from MyBioSource.com is a Rabbit Polyclonal antibody to ARPP-19e, and Ensa. This antibody recognizes Human, Mouse, Rat, Chicken/Bird, Porcine, Xenopus/Amphibian, and Zebrafish/Fish antigen. The ENSA Antibody (Center) has been validated for the following applications: ELISA, Flow Cytometry, and Western Blot.
Description
ENSA belongs to a highly
conserved cAMP-regulated phosphoprotein (ARPP) family. This protein
was identified as an endogenous ligand for the sulfonylurea
receptor, ABCC8/SUR1. ABCC8 is the regulatory subunit of the
ATP-sensitive potassium (KATP) channel, which is located on the
plasma membrane of pancreatic beta cells and plays a key role in
the control of insulin release from pancreatic beta cells. This
protein is thought to be an endogenous regulator of KATP channels.
In vitro studies have demonstrated that this protein modulates
insulin secretion through the interaction with KATP channel, and
this gene has been proposed as a candidate gene for type 2
diabetes